Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell fate and ensures clonal breadth

Affinity maturation depends on how efficiently germinal centers (GCs) positively select B cells in the light zone (LZ). Positively selected GC B cells recirculate between LZs and dark zones (DZs) and ultimately differentiate into plasmablasts (PBs) and memory B cells (MBCs). Current understanding of...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Nakagawa, Rinako, Toboso-Navasa, Amparo, Schips, Marta, Young, George, Bhaw-Rosun, Leena, Llorian-Sopena, Miriam, Chakravarty, Probir, Sesay, Abdul Karim, Kassiotis, George, Meyer-Hermann, Michael, Calado, Dinis Pedro
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812803/
https://ncbi.nlm.nih.gov/pubmed/33419925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016425118
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