Network Pharmacology and Experimental Evidence Identify the Mechanism of Astragaloside IV in Oxaliplatin Neurotoxicity

BACKGROUND AND OBJECTIVE: Neurotoxicity is a common side effect of oxaliplatin; the effect of current drugs such as methylcobalamin and gabapentine is not obvious. Astragaloside IV (AS-IV) is an important active ingredient of Astragali Radix, which can protect the nervous system and inhibit tumor gr...

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Publicat a:Drug Des Devel Ther
Autors principals: Xu, Jingyu, Guan, Zhenbiao, Wang, Xiaowei, Sun, Dazhi, Li, Yongjin, Pei, Bei, Lu, Ye, Yuan, Liangxi, Zhang, Xuan
Format: Artigo
Idioma:Inglês
Publicat: Dove 2021
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7811377/
https://ncbi.nlm.nih.gov/pubmed/33469263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S262818
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