Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes

BACKGROUND: During early HIV-1 infection, immunodominant T cell responses to highly variable epitopes lead to the establishment of immune escape virus variants. Here we assessed a type 1-polarized monocyte-derived dendritic cell (MDC1)-based approach to selectively elicit cytotoxic T lymphocyte (CTL...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Garcia-Bates, Tatiana M., Palma, Mariana L., Anderko, Renee R., Hsu, Denise C., Ananworanich, Jintanat, Korber, Bette T., Gaiha, Gaurav D., Phanuphak, Nittaya, Thomas, Rasmi, Tovanabutra, Sodsai, Walker, Bruce D., Mellors, John W., Piazza, Paolo A., Kroon, Eugene, Riddler, Sharon A., Michael, Nelson L., Rinaldo, Charles R., Mailliard, Robbie B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7811131/
https://ncbi.nlm.nih.gov/pubmed/33450518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.103175
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