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Molecular dynamics simulations of acyclic analogs of nucleic acids for antisense inhibition

For antisense applications, oligonucleotides must be chemically modified to be resistant to endogenous nucleases. Until now, antisense oligonucleotide (ASO) analogs have been synthesized and then tested for their ability to duplex with a target nucleic acid, usually RNA. In this work, using molecula...

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Vydáno v:Mol Ther Nucleic Acids
Hlavní autoři: Galindo-Murillo, Rodrigo, Cohen, Jack S., Akabayov, Barak
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810604/
https://ncbi.nlm.nih.gov/pubmed/33510941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.11.023
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