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Molecular dynamics simulations of acyclic analogs of nucleic acids for antisense inhibition

For antisense applications, oligonucleotides must be chemically modified to be resistant to endogenous nucleases. Until now, antisense oligonucleotide (ASO) analogs have been synthesized and then tested for their ability to duplex with a target nucleic acid, usually RNA. In this work, using molecula...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Mol Ther Nucleic Acids
Päätekijät: Galindo-Murillo, Rodrigo, Cohen, Jack S., Akabayov, Barak
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Gene & Cell Therapy 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810604/
https://ncbi.nlm.nih.gov/pubmed/33510941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.11.023
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