Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease

Mutations in proteolipid protein 1 (PLP1) result in failure of myelination and neurological dysfunction in the X-linked leukodystrophy Pelizaeus-Merzbacher disease (PMD)(1,2). Most PLP1 mutations, including point mutations and supernumerary copy variants, lead to severe and fatal disease. PLP1-null...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Nature
Main Authors: Elitt, Matthew S., Barbar, Lilianne, Shick, H. Elizabeth, Powers, Berit E., Maeno-Hikichi, Yuka, Madhavan, Mayur, Allan, Kevin C., Nawash, Baraa S., Gevorgyan, Artur S., Hung, Stevephen, Nevin, Zachary S., Olsen, Hannah E., Hitomi, Midori, Schlatzer, Daniela M., Zhao, Hien T., Swayze, Adam, LePage, David F., Jiang, Weihong, Conlon, Ronald A., Rigo, Frank, Tesar, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810164/
https://ncbi.nlm.nih.gov/pubmed/32610343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2494-3
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares