Tumor vasculature-targeted (10)B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy

BACKGROUND: p-Boronophenylalanine ((10)BPA) is a powerful (10)B drug used in current clinical trials of BNCT. For BNCT to be successful, a high (500 mg/kg) dose of (10)BPA must be administered over a few hours. Here, we report BNCT efficacy after rapid, ultralow-dose administration of either tumor v...

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Udgivet i:BMC Cancer
Main Authors: Yoneyama, Tohru, Hatakeyama, Shingo, Sutoh-Yoneyama, Mihoko, Yoshiya, Taku, Uemura, Tsuyoshi, Ishizu, Takehiro, Suzuki, Minoru, Hachinohe, Shingo, Ishiyama, Shintaro, Nonaka, Motohiro, Fukuda, Michiko N., Ohyama, Chikara
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809749/
https://ncbi.nlm.nih.gov/pubmed/33446132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07760-x
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