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PGE2 upregulates the Na(+)/K(+) ATPase in HepG2 cells via EP4 receptors and intracellular calcium

The Na(+)/K(+) ATPase is a key regulator of the hepatocytes ionic homeostasis, which when altered may lead to many liver disorders. We demonstrated recently, a significant stimulation of the Na(+)/K(+) ATPase in HepG2 cells treated with the S1P analogue FTY 720P, that was mediated through PGE2. The...

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Foilsithe in:PLoS One
Main Authors: Hodeify, Rawad, Chakkour, Mohamed, Rida, Reem, Kreydiyyeh, Sawsan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808645/
https://ncbi.nlm.nih.gov/pubmed/33444342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0245400
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