Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity: A Phase 2 Randomized Clinical Trial

IMPORTANCE: Antibody blockade of activin type II receptor (ActRII) signaling stimulates skeletal muscle growth. Previous clinical studies suggest that ActRII inhibition with the monoclonal antibody bimagrumab also promotes excess adipose tissue loss and improves insulin resistance. OBJECTIVE: To eva...

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Dettagli Bibliografici
Pubblicato in:JAMA Netw Open
Autori principali: Heymsfield, Steven B., Coleman, Laura A., Miller, Ram, Rooks, Daniel S., Laurent, Didier, Petricoul, Olivier, Praestgaard, Jens, Swan, Therese, Wade, Thomas, Perry, Robert G., Goodpaster, Bret H., Roubenoff, Ronenn
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Medical Association 2021
Soggetti:
Original Investigation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7807292/
https://ncbi.nlm.nih.gov/pubmed/33439265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2020.33457
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