Genome-wide association study of the TP53 R249S mutation in hepatocellular carcinoma with aflatoxin B1 exposure and infection with hepatitis B virus

BACKGROUND: Exposure to dietary aflatoxin B1 (AFB1) induces DNA damage and mutation in the TP53 gene at codon 249, known as the TP53 R249S mutation, and is a major risk factor for hepatocellular carcinoma (HCC). AFB1 and the hepatitis B virus (HBV) together exert synergistic effects that promote car...

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Dettagli Bibliografici
Pubblicato in:J Gastrointest Oncol
Autori principali: Han, Chuangye, Yu, Tingdong, Qin, Wei, Liao, Xiwen, Huang, Jianlu, Liu, Zhengtao, Yu, Long, Liu, Xiaoguang, Chen, Zhiwei, Yang, Chengkun, Wang, Xiangkun, Mo, Shutian, Zhu, Guangzhi, Su, Hao, Li, Jiaquan, Qin, Xue, Gui, Ying, Mo, Zengnan, Li, Lequn, Peng, Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: AME Publishing Company 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7807280/
https://ncbi.nlm.nih.gov/pubmed/33457005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jgo-20-510
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