Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial

A fungal metabolite, diatretol, has shown to be a promising antimalarial agent. Diatretol displayed potent in vitro antiparasitic activity against the Plasmodium falciparum K1 strain, with an IC(50) value of 378 ng ml(−1), as well as in vivo efficacy in a Plasmodium berghei-infected mice model, with...

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Bibliographic Details
Published in:J Antibiot (Tokyo)
Main Authors: Ishiyama, Aki, Hokari, Rei, Nonaka, Kenichi, Chiba, Takuya, Miura, Hiromi, Otoguro, Kazuhiko, Iwatsuki, Masato
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
Subjects:
Brief Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7807217/
https://ncbi.nlm.nih.gov/pubmed/33446930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41429-020-00390-2
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