Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis

BACKGROUND & AIMS: Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared on first pass through the hepatic circulation by enzymatic phosphorylation to fructose-1-phosphate via the ketohexokina...

詳細記述

保存先:
書誌詳細
出版年:JHEP Rep
主要な著者: Shepherd, Emma L., Saborano, Raquel, Northall, Ellie, Matsuda, Kae, Ogino, Hitomi, Yashiro, Hiroaki, Pickens, Jason, Feaver, Ryan E., Cole, Banumathi K., Hoang, Stephen A., Lawson, Mark J., Olson, Matthew, Figler, Robert A., Reardon, John E., Nishigaki, Nobuhiro, Wamhoff, Brian R., Günther, Ulrich L., Hirschfield, Gideon, Erion, Derek M., Lalor, Patricia F.
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2020
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7807164/
https://ncbi.nlm.nih.gov/pubmed/33490936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhepr.2020.100217
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