Inducible Deletion of YAP and TAZ in Adult Mouse Smooth Muscle Causes Rapid and Lethal Colonic Pseudo-Obstruction

BACKGROUND & AIMS: YAP (Yap1) and TAZ (Wwtr1) are transcriptional co-activators and downstream effectors of the Hippo pathway, which play crucial roles in organ size control and cancer pathogenesis. Genetic deletion of YAP/TAZ has shown their critical importance for embryonic development of the...

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Bibliographic Details
Published in:Cell Mol Gastroenterol Hepatol
Main Authors: Daoud, Fatima, Holmberg, Johan, Alajbegovic, Azra, Grossi, Mario, Rippe, Catarina, Swärd, Karl, Albinsson, Sebastian
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806867/
https://ncbi.nlm.nih.gov/pubmed/32992050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.09.014
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