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Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice
Progranulin (PGRN) has been reported to bind tumor necrosis factor (TNF) receptor and to inhibit TNFα signaling. We evaluated the effect of augmentation of TNFα signaling by PGRN deficiency on the progression of kidney injury. Eight-week-old PGRN knockout (KO) and wild-type (WT) mice were fed a stan...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2021
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7806827/ https://ncbi.nlm.nih.gov/pubmed/33441916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80940-8 |
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