Human α-synuclein overexpression in a mouse model of Parkinson’s disease leads to vascular pathology, blood brain barrier leakage and pericyte activation

The pathological hallmark of Parkinson’s disease (PD) is the formation of Lewy bodies containing aggregated alpha-synuclein (α-syn). Although PD is associated with these distinct histological changes, other pathological features such as microvascular alterations have been linked to neurodegeneration...

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Udgivet i:Sci Rep
Main Authors: Elabi, Osama, Gaceb, Abderahim, Carlsson, Robert, Padel, Thomas, Soylu-Kucharz, Rana, Cortijo, Irene, Li, Wen, Li, Jia-Yi, Paul, Gesine
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806665/
https://ncbi.nlm.nih.gov/pubmed/33441868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80889-8
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