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NSC348884 cytotoxicity is not mediated by inhibition of nucleophosmin oligomerization
Nucleophosmin (NPM) mutations causing its export from the nucleoli to the cytoplasm are frequent in acute myeloid leukemia (AML). Due to heterooligomerization of wild type NPM with the AML-related mutant, the wild-type becomes misplaced from the nucleoli and its functions are significantly altered....
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7806638/ https://ncbi.nlm.nih.gov/pubmed/33441774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80224-1 |
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