KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia

Rationale: Despite landmark therapy of chronic myelogenous leukemia (CML) with tyrosine kinase inhibitors (TKIs), drug resistance remains problematic. Cancer pathogenesis involves epigenetic dysregulation and in particular, histone lysine demethylases (KDMs) have been implicated in TKI resistance. W...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Zhang, Chengwan, Shen, Li, Zhu, Yifu, Xu, Ran, Deng, Zhikui, Liu, Xiaoning, Ding, Yihan, Wang, Chunling, Shi, Yuye, Bei, Liye, Wei, Dongping, Thorne, Rick F., Zhang, Xu Dong, Yu, Liang, Chen, Song
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806474/
https://ncbi.nlm.nih.gov/pubmed/33456567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.50571
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