Hematologic indices in individuals with pathogenic germline DICER1 variants

Pathogenic germline variants in DICER1 underlie an autosomal dominant, pleiotropic tumor-predisposition disorder. Murine models with the loss of DICER1 in hematopoietic stem cell progenitors demonstrate hematologic aberrations that include reductions in red and white blood cell counts, hemoglobin vo...

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Vydáno v:Blood Adv
Hlavní autoři: Vasta, Lauren M., Khan, Nicholas E., Higgs, Cecilia P., Harney, Laura A., Carr, Ann G., Harris, Anne K., Schultz, Kris Ann P., McMaster, Mary L., Stewart, Douglas R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2021
Témata:
Red Cells, Iron, and Erythropoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7805337/
https://ncbi.nlm.nih.gov/pubmed/33570641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002651
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