Overcoming bioprocess bottlenecks in the large-scale expansion of high-quality hiPSC aggregates in vertical-wheel stirred suspension bioreactors

BACKGROUND: Human induced pluripotent stem cells (hiPSCs) hold enormous promise in accelerating breakthroughs in understanding human development, drug screening, disease modeling, and cell and gene therapies. Their potential, however, has been bottlenecked in a mostly laboratory setting due to biopr...

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Publicat a:Stem Cell Res Ther
Autors principals: Borys, Breanna S., Dang, Tiffany, So, Tania, Rohani, Leili, Revay, Tamas, Walsh, Tylor, Thompson, Madalynn, Argiropoulos, Bob, Rancourt, Derrick E., Jung, Sunghoon, Hashimura, Yas, Lee, Brian, Kallos, Michael S.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7805206/
https://ncbi.nlm.nih.gov/pubmed/33436078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-02109-4
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