Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin

BACKGROUND: Iron overload, which is common in patients with haematological disorders, is known to have a suppressive effect on haematogenesis. However, the mechanism for this effect is still unclear. The antioxidant curcumin has been reported to protect against iron overload-induced bone marrow dama...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Cell Mol Biol Lett
Autori principali: Zhou, Shujuan, Sun, Lan, Qian, Shanhu, Ma, Yongyong, Ma, Ruye, Dong, Yuqing, Shi, Yifen, Jiang, Songfu, Ye, Haige, Shen, Zhijian, Zhang, Shenghui, Shen, Jianping, Yu, Kang, Wang, Siqian
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7805071/
https://ncbi.nlm.nih.gov/pubmed/33435886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s11658-020-00244-7
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