Sequential dual-drug delivery of BMP-2 and alendronate from hydroxyapatite-collagen scaffolds for enhanced bone regeneration

The clinical use of bioactive molecules in bone regeneration has been known to have side effects, which result from uncontrolled and supraphysiological doses. In this study, we demonstrated the synergistic effect of two bioactive molecules, bone morphogenic protein-2 (BMP-2) and alendronate (ALN), b...

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Publicat a:Sci Rep
Autors principals: Lee, Dongtak, Wufuer, Maierdanjiang, Kim, Insu, Choi, Tae Hyun, Kim, Byung Jun, Jung, Hyo Gi, Jeon, Byoungjun, Lee, Gyudo, Jeon, Ok Hee, Chang, Hak, Yoon, Dae Sung
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804460/
https://ncbi.nlm.nih.gov/pubmed/33436904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80608-3
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