LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH

It remains unclear how hepatic steatosis links to inflammation. Leukocyte cell-derived chemotaxin 2 (LECT2) is a hepatokine that senses fat in the liver and is upregulated prior to weight gain. The aim of this study was to investigate the significance of LECT2 in the development of nonalcoholic stea...

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Vydáno v:Sci Rep
Hlavní autoři: Takata, Noboru, Ishii, Kiyo-aki, Takayama, Hiroaki, Nagashimada, Mayumi, Kamoshita, Kyoko, Tanaka, Takeo, Kikuchi, Akihiro, Takeshita, Yumie, Matsumoto, Yukako, Ota, Tsuguhito, Yamamoto, Yasuhiko, Yamagoe, Satoshi, Seki, Akihiro, Sakai, Yoshio, Kaneko, Shuichi, Takamura, Toshinari
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804418/
https://ncbi.nlm.nih.gov/pubmed/33436955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80689-0
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