Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis

Nonribosomal peptide synthetases containing starter condensation domains direct the biosynthesis of nonribosomal lipopeptides, which generally exhibit wide bioactivities. The acyl chain has strong impacts on bioactivity and toxicity, but the lack of an in-depth understanding of starter condensation...

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Publicado en:Nat Commun
Autores principales: Zhong, Lin, Diao, Xiaotong, Zhang, Na, Li, Fengwei, Zhou, Haibo, Chen, Hanna, Bai, Xianping, Ren, Xintong, Zhang, Youming, Wu, Dalei, Bian, Xiaoying
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804268/
https://ncbi.nlm.nih.gov/pubmed/33436600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20548-8
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