Angiotensin-(1–7) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats

Sepsis can lead to shock, multiple organ failure, and even death. Platelets play an active role in the pathogenesis of sepsis-induced multiple organ failure. Angiotensin (Ang)-(1–7), a biologically active peptide, counteracts various effects of Ang II and attenuates inflammatory responses, reactive...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Tsai, Hsin-Jung, Shih, Chih-Chin, Chang, Kuang-Yi, Liao, Mei-Hui, Liaw, Wen-Jinn, Wu, Chin-Chen, Tsao, Cheng-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804205/
https://ncbi.nlm.nih.gov/pubmed/33436885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79902-x
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