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Big data and artificial intelligence discover novel drugs targeting proteins without 3D structure and overcome the undruggable targets

The discovery of targeted drugs heavily relies on three-dimensional (3D) structures of target proteins. When the 3D structure of a protein target is unknown, it is very difficult to design its corresponding targeted drugs. Although the 3D structures of some proteins (the so-called undruggable target...

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Bibliografski detalji
Izdano u:Stroke Vasc Neurol
Glavni autori: He, Huiqin, Liu, Benquan, Luo, Hongyi, Zhang, Tingting, Jiang, Jingwei
Format: Artigo
Jezik:Inglês
Izdano: BMJ Publishing Group 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804061/
https://ncbi.nlm.nih.gov/pubmed/33376199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/svn-2019-000323
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