Serial cryoFIB/SEM Reveals Cytoarchitectural Disruptions in Leigh Syndrome Patient Cells

The advancement of serial cryoFIB/SEM offers an opportunity to study large volumes of near-native, fully hydrated frozen cells and tissues at voxel sizes of 10 nm and below. We explored this capability for pathologic characterization of vitrified human patient cells by developing and optimizing a se...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Zhu, Yanan, Sun, Dapeng, Schertel, Andreas, Ning, Jiying, Fu, Xiaofeng, Gwo, Pam Pam, Watson, Alan M., Zanetti-Domingues, Laura C., Martin-Fernandez, Marisa L., Freyberg, Zachary, Zhang, Peijun
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2021
Assuntos:
Short Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7802768/
https://ncbi.nlm.nih.gov/pubmed/33096015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.10.003
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