The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma

BACKGROUND: The survival and proliferation of multiple myeloma (MM) cells in the bone marrow (BM) critically depend on interaction with stromal cells expressing the chemokine CXCL12. CXCL12 regulates the homing to the BM niche by mediating the transendothelial migration and adhesion/retention of the...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Ren, Zemin, Lantermans, Hildo, Kuil, Annemieke, Kraan, Willem, Arenzana-Seisdedos, Fernando, Kersten, Marie José, Spaargaren, Marcel, Pals, Steven T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7802348/
https://ncbi.nlm.nih.gov/pubmed/33436043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-021-01031-3
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