Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase

[Image: see text] Current chemotherapeutics for leishmaniasis have multiple deficiencies, and there is a need for new safe, efficacious, and affordable medicines. This study describes a successful drug repurposing approach that identifies the over-the-counter antihistamine, clemastine fumarate, as a...

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Veröffentlicht in:ACS Infect Dis
Hauptverfasser: Mina, John G. M., Charlton, Rebecca L., Alpizar-Sosa, Edubiel, Escrivani, Douglas O., Brown, Christopher, Alqaisi, Amjed, Borsodi, Maria Paula G., Figueiredo, Claudia P., de Lima, Emanuelle V., Dickie, Emily A., Wei, Wenbin, Coutinho-Silva, Robson, Merritt, Andy, Smith, Terry K., Barrett, Michael P., Rossi-Bergmann, Bartira, Denny, Paul W., Steel, Patrick G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7802075/
https://ncbi.nlm.nih.gov/pubmed/33291887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00546
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