Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies

In the search of biguanide-derived molecules against melanoma, we have discovered and developed a series of bioactive products and identified the promising new compound CRO15. This molecule exerted anti-melanoma effects on cells lines and cells isolated from patients including the ones derived from...

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Publicat a:Cell Death Dis
Autors principals: Jaune, Emilie, Cavazza, Elisa, Ronco, Cyril, Grytsai, Oleksandr, Abbe, Patricia, Tekaya, Nedra, Zerhouni, Marwa, Beranger, Guillaume, Kaminski, Lisa, Bost, Frédéric, Gesson, Maeva, Tulic, Meri, Hofman, Paul, Ballotti, Robert, Passeron, Thierry, Botton, Thomas, Benhida, Rachid, Rocchi, Stéphane
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801734/
https://ncbi.nlm.nih.gov/pubmed/33431809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03344-6
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