The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse

The self-antigen α-synuclein (α-syn) was recently shown to be associated with Parkinson’s disease (PD). Here we mapped the T cell receptor (TCR) repertoire of α-syn-specific T cells from six PD patients. The self-antigen α-syn-specific repertoire was compared to the repertoire of T cells specific fo...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Singhania, Akul, Pham, John, Dhanwani, Rekha, Frazier, April, Rezende Dutra, Juliana, Marder, Karen S., Phillips, Elizabeth, Mallal, Simon, Amara, Amy W., Standaert, David G., Sulzer, David, Peters, Bjoern, Sette, Alessandro, Lindestam Arlehamn, Cecilia S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801678/
https://ncbi.nlm.nih.gov/pubmed/33432042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79726-9
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