Disulfide disruption reverses mucus dysfunction in allergic airway disease

Airway mucus is essential for lung defense, but excessive mucus in asthma obstructs airflow, leading to severe and potentially fatal outcomes. Current asthma treatments have minimal effects on mucus, and the lack of therapeutic options stems from a poor understanding of mucus function and dysfunctio...

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Foilsithe in:Nat Commun
Main Authors: Morgan, Leslie E., Jaramillo, Ana M., Shenoy, Siddharth K., Raclawska, Dorota, Emezienna, Nkechinyere A., Richardson, Vanessa L., Hara, Naoko, Harder, Anna Q., NeeDell, James C., Hennessy, Corinne E., El-Batal, Hassan M., Magin, Chelsea M., Grove Villalon, Diane E., Duncan, Gregg, Hanes, Justin S., Suk, Jung Soo, Thornton, David J., Holguin, Fernando, Janssen, William J., Thelin, William R., Evans, Christopher M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2021
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801631/
https://ncbi.nlm.nih.gov/pubmed/33431872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20499-0
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