PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma

CD276 (also known as B7–H3, an immune checkpoint molecule) is aberrantly overexpressed in many cancers. However, the upregulation mechanism and in particular, whether oncogenic signaling has a role, is unclear. Here we demonstrate that a pro-oncogenic kinase PBK, the expression of which is associate...

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Udgivet i:Oncogenesis
Main Authors: Wang, Meng-Yao, Qi, Bin, Wang, Fang, Lin, Zhi-Rui, Li, Ming-Yi, Yin, Wen-Jing, Zhu, Yan-Yi, He, Lu, Yu, Yi, Yang, Fang, Liu, Jin-Quan, Chen, Dong-Ping
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801519/
https://ncbi.nlm.nih.gov/pubmed/33431797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00293-9
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