Suppressing BCL-XL increased the high dose androgens therapeutic effect to better induce the Enzalutamide-resistant prostate cancer autophagic cell death

Most patients with advanced prostate cancer (PCa) initially respond well to androgen deprivation therapy (ADT) with antiandrogens, but most of them eventually become resistant to ADT. Here, we found that the antiandrogen Enzalutamide-resistant (EnzR) PCa cells can be suppressed by hyper-physiologica...

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Bibliografski detalji
Izdano u:Cell Death Dis
Glavni autori: Xiang, Zhendong, Sun, Yin, You, Bosen, Zhang, Meng, Huang, Chiping, Yu, Junfeng, You, Xiangyun, Wu, Denglong, Chang, Chawnshang
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801470/
https://ncbi.nlm.nih.gov/pubmed/33431795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03321-z
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