Suppressing BCL-XL increased the high dose androgens therapeutic effect to better induce the Enzalutamide-resistant prostate cancer autophagic cell death

Most patients with advanced prostate cancer (PCa) initially respond well to androgen deprivation therapy (ADT) with antiandrogens, but most of them eventually become resistant to ADT. Here, we found that the antiandrogen Enzalutamide-resistant (EnzR) PCa cells can be suppressed by hyper-physiologica...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Xiang, Zhendong, Sun, Yin, You, Bosen, Zhang, Meng, Huang, Chiping, Yu, Junfeng, You, Xiangyun, Wu, Denglong, Chang, Chawnshang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801470/
https://ncbi.nlm.nih.gov/pubmed/33431795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03321-z
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