The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus

In humans, inactivating mutations in MLL4, which encodes a histone H3-lysine 4-methyltransferase, lead to Kabuki syndrome (KS). While dwarfism is a cardinal feature of KS, the underlying etiology remains unclear. Here we report that Mll4 regulates the development of growth hormone-releasing hormone...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Huisman, Christian, Kim, Young A., Jeon, Shin, Shin, Bongjin, Choi, Jeonghoon, Lim, Su Jeong, Youn, Sung Min, Park, Younjung, K. C., Medha, Kim, Sangsoo, Lee, Soo-Kyung, Lee, Seunghee, Lee, Jae W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801453/
https://ncbi.nlm.nih.gov/pubmed/33431871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20511-7
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