Plasminogen activator inhibitor-1 reduces cardiac fibrosis and promotes M2 macrophage polarization in inflammatory cardiomyopathy

Plasminogen activator inhibitor-1 (PAI-1) has a cardioprotective function in mice by repressing cardiac fibrosis through TGF-β and plasminogen-mediated pathways. In addition it is known to be involved in the recruitment and polarization of monocytes/macrophages towards a M2 phenotype in cancer. Here...

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Bibliographic Details
Published in:Basic Res Cardiol
Main Authors: Baumeier, Christian, Escher, Felicitas, Aleshcheva, Ganna, Pietsch, Heiko, Schultheiss, Heinz-Peter
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2021
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Original Contribution
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801308/
https://ncbi.nlm.nih.gov/pubmed/33432417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-020-00840-w
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