Stimulation of Sigma-1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment

Sigma-1 receptor (Sig1R), a chaperone in the endoplasmic reticulum (ER) membrane, has been implicated in cardiac hypertrophy; however, its role in cardiac fibroblast activation has not been established. This study investigated the possible association between Sig1R and this activation by subjecting...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Qu, Jing, Li, Miaoling, Li, Dongxu, Xin, Yanguo, Li, Junli, Lei, Song, Wu, Wenchao, Liu, Xiaojing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801073/
https://ncbi.nlm.nih.gov/pubmed/33488945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/8836818
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