Pristimerin Protects Against OVX-Mediated Bone Loss by Attenuating Osteoclast Formation and Activity via Inhibition of RANKL-Mediated Activation of NF-κB and ERK Signaling Pathways

INTRODUCTION: Osteoporosis is an osteolytic bone condition characterized by decreased bone strength and increased bone fragility. It is the result of elevated formation or activity of bone-resorbing osteoclasts. Although current therapeutic agents are efficacious against osteoclast-mediated bone los...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Li, Xuedong, Lin, Xixi, Wu, Zuoxing, Su, Yuangang, Liang, Jiamin, Chen, Runfeng, Yang, Xue, Hou, Lei, Zhao, Jinmin, Liu, Qian, Xu, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7800467/
https://ncbi.nlm.nih.gov/pubmed/33442237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S283694
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