Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic

Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in coronavirus disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrated that R406 can abrogate the release of NETs. These data provide...

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Bibliografiske detaljer
Udgivet i:J Infect Dis
Main Authors: Strich, Jeffrey R, Ramos-Benitez, Marcos J, Randazzo, Davide, Stein, Sydney R, Babyak, Ashley, Davey, Richard T, Suffredini, Anthony F, Childs, Richard W, Chertow, Daniel S
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7799006/
https://ncbi.nlm.nih.gov/pubmed/33367731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiaa789
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