Chronic lymphocytic leukemia B-cell-derived TNFα impairs bone marrow myelopoiesis

TNFα is implicated in chronic lymphocytic leukemia (CLL) immunosuppression and disease progression. TNFα is constitutively produced by CLL B cells and is a negative regulator of bone marrow (BM) myelopoiesis. Here, we show that co-culture of CLL B cells with purified normal human hematopoietic stem...

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Publicado no:iScience
Main Authors: Manso, Bryce A., Krull, Jordan E., Gwin, Kimberly A., Lothert, Petra K., Welch, Baustin M., Novak, Anne J., Parikh, Sameer A., Kay, Neil E., Medina, Kay L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797930/
https://ncbi.nlm.nih.gov/pubmed/33458625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101994
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