Synthesis of 4-oxotetrahydropyrimidine-1(2H)-carboxamides derivatives as capsid assembly modulators of hepatitis B virus

We report herein the synthesis and evaluation of phenyl ureas derived from 4-oxotetrahydropyrimidine as novel capsid assembly modulators of hepatitis B virus (HBV). Among the derivatives, compound 27 (58031) and several analogs showed an activity of submicromolar EC(50) against HBV and low cytotoxic...

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Detalhes bibliográficos
Publicado no:Med Chem Res
Main Authors: Hwang, Nicky, Ban, Haiqun, Chen, Junjun, Ma, Julia, Liu, Hui, Lam, Patrick, Kulp, John, Menne, Stephan, Chang, Jinhong, Guo, Ju-Tao, Du, Yanming
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797712/
https://ncbi.nlm.nih.gov/pubmed/33456291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00044-020-02677-3
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