Reversine, a selective MPS1 inhibitor, induced autophagic cell death via diminished glucose uptake and ATP production in cholangiocarcinoma cells

Reversine is a selective inhibitor of mitotic kinase monopolar spindle 1 (MPS1) and has been reported as an anticancer agent in various cancers. The effects of reversine on bile duct cancer, cholangiocarcinoma (CCA), a lethal cancer in Northeastern Thailand, were investigated. This study reports tha...

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Détails bibliographiques
Publié dans:PeerJ
Auteurs principaux: Prajumwongs, Piya, Waenphimai, Orawan, Vaeteewoottacharn, Kulthida, Wongkham, Sopit, Sawanyawisuth, Kanlayanee
Format: Artigo
Langue:Inglês
Publié: PeerJ Inc. 2021
Sujets:
Biochemistry
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797171/
https://ncbi.nlm.nih.gov/pubmed/33505802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.10637
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