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Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing
GWAS have identified numerous SNPs associated with prostate cancer risk. One such SNP is rs10993994. It is located in the β-microseminoprotein (MSMB) promoter region, mediates MSMB prostate secretion levels, and linked to mRNA expression changes in both MSMB and the adjacent gene NCOA4. In addition,...
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| Publicado no: | Gene |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7796996/ https://ncbi.nlm.nih.gov/pubmed/33122083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2020.145265 |
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