The Thyroid Hormone Transporter Mct8 Restricts Cathepsin-Mediated Thyroglobulin Processing in Male Mice through Thyroid Auto-Regulatory Mechanisms That Encompass Autophagy

The thyroid gland is both a thyroid hormone (TH) generating as well as a TH responsive organ. It is hence crucial that cathepsin-mediated proteolytic cleavage of the precursor thyroglobulin is regulated and integrated with the subsequent export of TH into the blood circulation, which is enabled by T...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Venugopalan, Vaishnavi, Al-Hashimi, Alaa, Rehders, Maren, Golchert, Janine, Reinecke, Vivien, Homuth, Georg, Völker, Uwe, Manirajah, Mythili, Touzani, Adam, Weber, Jonas, Bogyo, Matthew S., Verrey, Francois, Wirth, Eva K., Schweizer, Ulrich, Heuer, Heike, Kirstein, Janine, Brix, Klaudia
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796480/
https://ncbi.nlm.nih.gov/pubmed/33466458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010462
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