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Relation of Metal-Binding Property and Selective Toxicity of 8-Hydroxyquinoline Derived Mannich Bases Targeting Multidrug Resistant Cancer Cells

SIMPLE SUMMARY: Effective treatment of cancer is often limited by the resistance of cancer cells to chemotherapy. A well-described mechanism supporting multidrug resistance (MDR) relies on the efflux of toxic drugs from cancer cells, mediated by P-glycoprotein (Pgp). Circumventing Pgp-mediated resis...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancers (Basel)
Prif Awduron: Pape, Veronika F.S., Gaál, Anikó, Szatmári, István, Kucsma, Nóra, Szoboszlai, Norbert, Streli, Christina, Fülöp, Ferenc, Enyedy, Éva A., Szakács, Gergely
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796460/
https://ncbi.nlm.nih.gov/pubmed/33466433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13010154
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