The model structure of the hammerhead ribozyme formed by RNAs of reciprocal chirality

RNA-based tools are frequently used to modulate gene expression in living cells. However, the stability and effectiveness of such RNA-based tools is limited by cellular nuclease activity. One way to increase RNA’s resistance to nucleases is to replace its D-ribose backbone with L-ribose isomers. Thi...

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Bibliografiske detaljer
Udgivet i:Biosci Rep
Main Authors: Wyszko, Eliza, Popenda, Mariusz, Gudanis, Dorota, Sarzyńska, Joanna, Belter, Agnieszka, Perrigue, Patrick, Skowronek, Paweł, Rolle, Katarzyna, Barciszewski, Jan
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2021
Fag:
Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796190/
https://ncbi.nlm.nih.gov/pubmed/33351058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20203424
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