Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells

Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants produced by incomplete combustion of organic matter. They induce their own metabolism by upregulating xenobiotic-metabolizing enzymes such as cytochrome P450 monooxygenase 1A1 (CYP1A1) by activating the aryl hydrocarbon receptor (A...

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Publicado en:Int J Mol Sci
Main Authors: Goedtke, Lisa, Sprenger, Heike, Hofmann, Ute, Schmidt, Felix F., Hammer, Helen S., Zanger, Ulrich M., Poetz, Oliver, Seidel, Albrecht, Braeuning, Albert, Hessel-Pras, Stefanie
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796163/
https://ncbi.nlm.nih.gov/pubmed/33396476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010372
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