Clinical Utility of Plasma KRAS, NRAS and BRAF Mutational Analysis with Real Time PCR in Metastatic Colorectal Cancer Patients—The Importance of Tissue/Plasma Discordant Cases

Background: Tumor tissue (T) mutational analysis represents the standard for metastatic colorectal cancer (mCRC); however, circulating tumor DNA (ctDNA) detected by liquid biopsy in plasma (PL) can better represent tumor heterogeneity. Methods: mCRC patients undergoing standard first-line chemothera...

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Detalhes bibliográficos
Publicado no:J Clin Med
Main Authors: Formica, Vincenzo, Lucchetti, Jessica, Doldo, Elena, Riondino, Silvia, Morelli, Cristina, Argirò, Renato, Renzi, Nicola, Nitti, Daniele, Nardecchia, Antonella, Dell’Aquila, Emanuela, Ferroni, Patrizia, Guadagni, Fiorella, Palmieri, Giampiero, Orlandi, Augusto, Roselli, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794782/
https://ncbi.nlm.nih.gov/pubmed/33383664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm10010087
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