Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes

The long-standing perception of Protein Kinase C (PKC) as a family of oncoproteins has increasingly been challenged by evidence that some PKC isoforms may act as tumor suppressors. To explore the hypothesis that activation, rather than inhibition, of these isoforms is critical for anticancer activit...

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Pubblicato in:Sci Rep
Autori principali: Cullen, Jason K., Boyle, Glen M., Yap, Pei-Yi, Elmlinger, Stefan, Simmons, Jacinta L., Broit, Natasa, Johns, Jenny, Ferguson, Blake, Maslovskaya, Lidia A., Savchenko, Andrei I., Mirzayans, Paul Malek, Porzelle, Achim, Bernhardt, Paul V., Gordon, Victoria A., Reddell, Paul W., Pagani, Alberto, Appendino, Giovanni, Parsons, Peter G., Williams, Craig M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794351/
https://ncbi.nlm.nih.gov/pubmed/33420238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80397-9
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