Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds

Novel bacterial type II topoisomerase inhibitors (NBTIs) stabilize single-strand DNA cleavage breaks by DNA gyrase but their exact mechanism of action has remained hypothetical until now. We have designed a small library of NBTIs with an improved DNA gyrase-binding moiety resulting in low nanomolar...

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Publicado no:Nat Commun
Main Authors: Kolarič, Anja, Germe, Thomas, Hrast, Martina, Stevenson, Clare E. M., Lawson, David M., Burton, Nicolas P., Vörös, Judit, Maxwell, Anthony, Minovski, Nikola, Anderluh, Marko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794245/
https://ncbi.nlm.nih.gov/pubmed/33420011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20405-8
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