Development of a structural epitope mimic: an idiotypic approach to HCV vaccine design

HCV vaccine development is stymied by the high genetic diversity of the virus and the variability of the envelope glycoproteins. One strategy to overcome this is to identify conserved, functionally important regions—such as the epitopes of broadly neutralizing antibodies (bNAbs)—and use these as a b...

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Veröffentlicht in:NPJ Vaccines
Hauptverfasser: Cowton, Vanessa M., Owsianka, Ania M., Fadda, Valeria, Ortega-Prieto, Ana Maria, Cole, Sarah J., Potter, Jane A., Skelton, Jessica K., Jeffrey, Nathan, Di Lorenzo, Caterina, Dorner, Marcus, Taylor, Garry L., Patel, Arvind H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794244/
https://ncbi.nlm.nih.gov/pubmed/33420102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-020-00269-1
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