Cyclin Pathway Genomic Alterations Across 190,247 Solid Tumors: Leveraging Large‐Scale Data to Inform Therapeutic Directions

BACKGROUND: We describe the landscape of cyclin and interactive gene pathway alterations in 190,247 solid tumors. METHODS: Using comprehensive genomic profiling (315 genes, >500× coverage), samples were analyzed for alterations in activating/sensitizing cyclin genes (CDK4 amplification, CDK6 ampl...

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Bibliografische gegevens
Gepubliceerd in:Oncologist
Hoofdauteurs: Jardim, Denis L., Millis, Sherri Z., Ross, Jeffrey S., Woo, Michelle Sue‐Ann, Ali, Siraj M., Kurzrock, Razelle
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Inc. 2020
Onderwerpen:
Cancer Diagnostics and Molecular Pathology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794175/
https://ncbi.nlm.nih.gov/pubmed/32885893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2020-0509
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